Clinical Research


Our software is used in co-operation projects for consistent analysis of large image data sets, as well as to find new meaningful parameters from today’s medical images. 

Kärkkäinen M. et al.
Primary reconstruction of orbital fractures using patient-specific titanium milled implants: the Helsinki protocol
​British Journal of Oral and Maxillofacial Surgery (2018)

Snäll J. et al.:
Does postoperative orbital volume predict postoperative globe malposition after blow-out fracture reconstruction? A 6-month clinical follow-up study
Oral and Maxillofacial Surgery (2019)

Chepurnyi Y. et al.:
Reliability of orbital volume measurements based on CT segmentation: validation of different algorithms in orbital trauma patients
Journal of Cranio- Maxillofacial Surgery (2020)

Lehtinen V. et al.:
Zygomatico-orbital fracture dislocation in surgical treatment – novel 3D software automated analysis
Journal of Oral and Maxillofacial Surgery (2020)

Thieringer, F. et al.:
Three-Dimensional analysis of isolated orbital floor fractures pre- and post-reconstruction with standard titanium meshes and “Hybrid” Patient-Specific Implants
Journal of Clinical Medicine (2020)

Chepurnyi Y. et al.:
Automatic evaluation of the orbital shape after application of conventional and patient-specific implants: Correlation of initial trauma patterns and outcome
Journal of Oral Biology and Craniofacial Research (2020)

Saloniemi M. et al.;
Computer-aided fracture size measurement in orbital fractures—An alternative to manual evaluation
Craniomaxillofacial Trauma & Reconstruction (2020)

Lowe B. et al.;
FEA evaluation of material stiffness changes for a polymer assisted 3D polycaprolactone/β-tricalcium phosphate scaffold in a mandibular defect reconstruction model
Ceramics International (2020)

Suojärvi N. et al.:
Computer‐aided 3D analysis of anatomy and radiographic parameters of the distal radius ​
Clinical Anatomy (2020)

Kvarda P. et al.;
3D assessment in posttraumatic ankle osteoarthritis
Foot & Ankle International (2020)

Suojärvi N. et al.;
Radiographic measurements of the normal distal radius: reliability of computer-aided CT versus physicians’ radiograph interpretation
Journal of Hand Surgery (2020)

Suojärvi N.
Cone Beam Computed Tomography of the Wrist – Analysis of Radiographic Measurements and Diagnosis of Intra-Articular Injuries
University of Helsinki/Dissertations and thesis/Doctoral dissertations/Faculty of medicine (2021)

​Pyötsiä K. et al.;
Three-dimensional computer-aided analysis of 293 isolated blowout fractures – which radiological findings guide treatment decision?
Journal of Oral and Maxillofacial Surgery (2021)

​Kvarda P. et al.;
High reliability for semiautomated 3D measurements based on weightbearing CT scans 
Foot & Ankle International (2021)

​Sippo R. et al.;
Computer-based three-dimensional measurement of carpal alignment: measurement techniques and normal ranges
Journal of Hand Surgery (2021)

Fick T. et al.;
Fully automatic brain tumor segmentation for 3D evaluation in augmented reality
Journal of Neurosurgery (2021)

van Doormaal. et al.;
Fully automatic adaptive meshing based segmentation of the ventricular system for augmented reality visualization and navigation
World Neurosurgery (2021)

Krähenbühl. et al.;
Assessment of Progressive Collapsing Foot Deformity using semi-automated 3D measurements derived from weightbearing CT scans
Foot & Ankle International (2021)

Conti. et al.;
Correlation of  different methods of measuring pronation of the first metatarsal on weight bearing CT scans
Foot & Ankle International (2021)

Patel. et al.;
Pronation on weightbearing radiographs does not correlate with pronation from weightbearing CT scans
Foot and Ankle Surgery (2021)

Michalski, et al.;
Abnormal bone morphology in Charcot-Marie-Tooth disease
Foot & Ankle International (2021)

Ortolani, et al.;
Angular and linear measurements of adult flexible flatfoot via weight-bearing CT scans and 3D bone reconstruction tools
Nature Scientific Reports (2021)

Clarke A, et al.;
The Association of Crista Volume With Sesamoid Position as Measured From 3D Reconstructions of Weightbearing CT Scans
Foot & Ankle International (2021)

Carvalho, et al.;
Comparison between Weightbearing-CT semiautomatic and manual measurements in Hallux Valgus
Foot and Ankle Surgery (2022)

An, et al.;
Cavovarus With a Twist: Midfoot Coronal and Axial Plane Rotational Deformity in Charcot-Marie-Tooth Disease
Foot & Ankle International (2022)

Sangoi, et al.;
​2D Manual vs 3D Automated Assessment of Alignment in Normal and Charcot-Marie-Tooth Cavovarus Feet Using Weightbearing CT
Foot & Ankle International (2022)

Carvalho, et al.;
Automated three-dimensional distance and coverage mapping of hallux valgus: a case-control study
Journal of the Foot & Ankle (2022)

Mallavarapu, et al.;
Agreement between semiautomatic and manual measurement of selected parameters on weight-bearing computed tomography images in total ankle replacement: a retrospective study
Journal of the Foot & Ankle (2022)

Chepurnyi Y. et al.; 
Clinical application of automated virtual orbital reconstruction for orbital fracture management with patient-specific implants: a prospective comparative study​
Journal of Cranio-Maxillofacial Surgery (2022)

Burssens A. et al.;
Supramalleolar Osteotomy for Ankle Varus Deformity Alters Subtalar Joint Alignment
Foot & Ankle International (2022)

Foerster Y. et al.;
Ultra-High Molecular Weight Polyethylene (marPOR) is a Suitable Material for the Reconstruction of Orbital Floor Fracture Defects in Human Cadavers
Journal of Maxillofacial and Oral Surgery (2022)

Lehtinen V. et al.;
Primary reconstruction of combined orbital and zygomatic complex fractures with patient-specific milled titanium implants – A retrospective study
Journal of Cranio-Maxillofacial Surgery (2022)

Honigmann P. et al.;
Distance mapping in three-dimensional virtual surgical planning in hand, wrist and forearm surgery: a tool to avoid mistakes
International Journal of Computer Assisted Radiology and Surgery (2022)

Behrens A. et al.;
Coverage maps demonstrate 3D Chopart joint subluxation in weightbearing CT of progressive collapsing foot deformity
Nature Scientific Reports (2022)

Carvalho K. et al.;
The Use of Advanced Semiautomated Bone Segmentation in Hallux Rigidus
Foot & Ankle Orthopaedics (2022)

Zaidi R. et al.;
Semi-automated 3-dimensional analysis of the normal foot and ankle using weight bearing-CT – A report of normal values and bony relationships
Foot and Ankle Surgery (2022)

Wellenberg R. et al.;
Assessment of foot deformities in individuals with cerebral palsy using weight bearing CT
Skeletal Radiology  (2022)

Jasper R. et al.;
Three-dimensional assessment of hallux valgus correction using the Lapicotton technique
Journal of the Foot and Ankle  (2022)

Dibbern K. et al.;
Ankle syndesmotic instability assessment using a three-dimensional distance mapping algorithm: a cadaveric pilot WBCT study
Journal of the Foot and Ankle  (2022)

Keller M. et al.;
Artificial intelligence in patient-specific hand surgery: a scoping review of literature
International Journal of Computer Assisted Radiology and Surgery  (2023)

Autio A. et al.;
Should individual timeline and serial CT/MRI panels of all patients be presented in acute brain insult cohorts? A pilot study of 45 patients with decompressive craniectomy after aneurysmal subarachnoid hemorrhage
Acta Neurochirurgica (2023)

Ranjit S. et al.;
Assessing the coronal plane deformity in Charcot Marie Tooth Cavovarus feet using automated 3D measurements
Foot and Ankle Surgery (2023)

Efrima B. et al.;
Classification of the Os Calcis Subtalar Morphology in Symptomatic Flexible Pediatric Pes Planus Deformity Using Weightbearing CT and Distance Mapping
Foot and Ankle International (2023)

Höglund T. et al.;
Three-dimensional carpal alignment: computer-aided CT analysis of carpal axes and normal ranges
Journal of Hand Surgery (2023)

Dibbern K. et al.;
Distance mapping and volumetric assessment of the ankle and syndesmotic joints in progressive collapsing foot deformity
Nature Scientific Reports (2023)

Knutson K. et al.;
Joint coverage analysis in progressive collapsing foot deformity.​
Journal of Orthopaedic Research (2023)

Efrima B. et al.;
Axial Rotation Analysis in Total Ankle Arthroplasty Using Weight-Bearing Computer Tomography and Three-dimensional Modeling
Foot and Ankle Surgery (2023)

Kvarda P. et al.;
Effect of total ankle replacement on the 3-dimensional subtalar joint alignment in varus ankle osteoarthritis
Foot and Ankle Surgery (2023)

Efrima B. et al.;
Reliability of Cone Beam Weightbearing Computed Tomography Analysis of Total Ankle Arthroplasty Positioning and Comparison to Weightbearing X-Ray Measurements
Foot and Ankle International (2023)

Burssens A. et al.;
Supramalleolar Osteotomies in Cavovarus Foot Deformity
Why Patient-Specific Instruments Make a Difference

Foot & Ankle Clinics  (2023)

Efrima B. et al.;
Three-Dimensional Distance Mapping to Identify Safe Zones for Lateral Column Lengthening
Foot & Ankle International (2023)

Peiffer M. et al.;
Application of external torque enhances the detection of subtle syndesmotic ankle instability in a weight-bearing CT
Knee surgery, Sports Traumatology, Arthroscopy (2023)

Meilak E. et al.;
Subtalar joint axis alignments in pathological feet of children with cerebral palsy
Gait & Posture (2023)

Li J. et al.;
Diagnostic applications and benefits of weightbearing CT in the foot and ankle: A systematic review of clinical studies
Foot and Ankle Surgery (2023)

Usuelli F. et al.;
Outcomes of Lateral Transfibular Approach for Total Ankle Replacement
Foot and Ankle Clinics (2023)

Dhont T. et al.;
Ins and Outs of the Ankle Syndesmosis from a 2D to 3D CT Perspective 
Applied Sciences (2023)

Kos T. et al.;
​Effect of Intraoperative Mixed-Reality use on Nonsurgical Team Members in the Neurosurgical Operating Room: An Explorative Study
World Neurosurgery (2023)

de Cesar Netto C. et al.;
Effect of Peritalar Subluxation Correction for Progressive Collapsing Foot Deformity on Patient-Reported Outcomes
Foot & Ankle International (2023)

Smolinski M. et al.;
A Comparison of Imaging Outcomes From 2 Weightbearing CT Modalities
Foot & Ankle International (2023)

Raes L. et al.;
Medializing Calcaneal Osteotomy for Progressive Collapsing Foot Deformity Alters the Three-Dimensional Subtalar Joint Alignment​.
Foot & Ankle Surgery (2023)

Peterson A. et al.;
Automatic anatomical foot and ankle coordinate toolbox.
Frontiers in Bioengineering and Biotechnology (2023)

Lintz F. et al.;
Ankle Joint Bone Density Distribution Correlates with Overall 3-Dimensional Foot and Ankle Alignment.
The Journal of Bone and Joint Surgery (2023)

Waris E. et al.;
Association of ulnar variance with three-dimensional carpal alignment and demographics in asymptomatic volunteers.
 Acta Radiologica (2023)

Sippo R. et al.;
Comparison of computer-aided and manual measurements in the evaluation of carpal alignment.
 The Journal of Hand Surgery (2023)

Colombo E. et al.;
Mixed Reality for Cranial Neurosurgical Planning: A Single-Center Applicability Study With the First 107 Subsequent Holograms
Operative Neurosurgery (2023)

Buckwalter J. et al.;
Altered Ulnar Variance With Full-Body Weight-bearing During Handstands With Upper Extremity Weight-bearing CT
The Journal of Hand Surgery (2023)

Lee S-W. et al.;
Comparison of the Usefulness of Computer-Assisted Three-Dimensional Analysis and Weight-Bearing Radiographs in Ankle Osteoarthritis
Clinics in Orthopedic Surgery (2024)

Sigron G. et al.;
Insights into Orbital Symmetry: A Comprehensive Retrospective Study of 372 Computed Tomography Scans
Journal of Clinical Medicine (2024)

Peiffer M. et al.;
The Influence of Talar Displacement on Articular Contact Mechanics: A 3D Finite Element Analysis Study Using Weightbearing Computed Tomography
Foot and Ankle International (2024)

Andres L. et al.;
Association Between Weightbearing CT and MRI Findings in Progressive Collapsing Foot Deformity.​
Foot and Ankle International (2024)

Song J. et al.;
3D Analysis of Joint-Sparing Charcot-Marie-Tooth Surgery Effect on Initial Standing Foot Alignment
Foot and Ankle International (2024)

Efrima B. et al.;
Enhancing precision in osteochondral lesions of the talus measurements and improving agreement in surgical decision-making using weight-bearing computed tomography and distance mapping
Knee Surgery, Sports Traumatology, Arthroscopy (2024)

Malhotra K. et al.;
Forefoot Morphotypes in Cavovarus Feet: A Novel Assessment of Deformity
Foot and Ankle International (2024)

Kontio R. et al.;
Automated 3-D Computer-Aided Measurement of the Bony Orbit: Evaluation of Correlations among Volume, Depth, and Surface Area
Journal of Personalized Medicine (2024)

Eatough Z. et al.;
Static posture weightbearing joint angle differences in patients with varus ankle osteoarthritis
Gait & Posture (2024)

Peiffer M. et al.;
Normative contact mechanics of the ankle Joint: Quantitative assessment utilizing bilateral weightbearing CT
Journal of Biomechanics (2024)

Nunes G. et al.;
Biomechanical Consequences of Zadek Osteotomy in Insertional Achilles Tendinopathy: A Virtual Surgical Simulation Study
Foot and Ankle Surgery  (2024)

Elicegui S. et al.;
Investigation of subtle Lisfranc injuries using weight-bearing computed tomography
Journal of the Foot and Ankle (2024)

Kush S. et al.;
Preoperative Degenerative Changes at the Tibial Sesamoid-Metatarsal Joint in Hallux Valgus: Association With Postoperative Patient-Reported Outcomes After Modified Lapidus Procedure
Foot and Ankle Orthopaedics (2024)

Kettunen J. et al.;
Cone-beam computed tomography imaging and three-dimensional analysis of midfoot joints during non-weightbearing and weightbearing in 11 healthy feet
Acta Radiologica (2024)

Krüger L. et al.;
Influence of the transverse tarsal arch on radiological components of progressive collapsing foot deformity
Journal of Orthopaedic Research (2024)

Jones M. et al.;
Quantification of First Metatarsal Joint Surface Interactions in Hallux Rigidus Using Distance and Coverage Mapping: A Case-Control Study
Foot & Ankle International (2024)

Michalski M. et al.;
Méary’s Angle Decoded: 3D Analysis of First Ray Plantarflexion Deformity in Charcot-Marie Tooth Disease
Foot & Ankle Surgery (2024)

Starck E. et al.;
Are Age and Trauma Mechanism Associated with Volume Change in the Fractures of the Bony Orbit?
 Journal of Clinical Medicine (2024) 

Efrima B. et al.;
Total Ankle Arthroplasty as a Correction Tool for Foot Deformities: Analyzing the Impact on Medial Column Alignment Adaptation Through Weightbearing Computed Tomography
 Foot & Ankle International (2024) 

Usuelli F. et al.;
Reliability analysis of WBCT-derived 3D models for comparing preoperative and postoperative alignment in total ankle arthroplasty
 Foot & Ankle Surgery (2024) 

Peiffer M. et al.;
Congruent Weber-B ankle fractures do not alter tibiotalar contact mechanics
 Scientific Reports (2024) 

Scigliano N. et al.;
The effect of full-body weight-bearing on palmar pressure distribution in collegiate-level gymnasts
Sports Biomechanics (2024) 

Wang C-S. et al.;
Comparative Analysis of Structural Differences in Progressive Collapsing Foot Deformity With and Without Hallux Valgus
Foot and Ankle International (2024) 

Juric D. et al.;
Integrating weightbearing CT findings into evaluation of conventional radiographs in progressive collapsing foot deformity
Foot and Ankle Surgery (2024) 

Alanen M. et al.;
Comparative Computer-Aided Analysis of Three-Dimensional Carpal Alignment in Scapholunate Advanced Collapse and Healthy Wrists
The Journal of Hand Surgery (2024) 

Michalski M. et al.;
Weightbearing Computed Tomography Evaluation of Acute SER4a Ankle Fractures
Foot & Ankle International (2024) 

Peterson A. et al.;
Talar Morphology of Charcot-Marie-Tooth Patients With Cavovarus Feet
Foot & Ankle International (2025)

de Cesar Netto C. et al.;
Cadaveric Diagnostic Study of Subtle Syndesmotic Instability Using a 3-Dimensional Weight-Bearing CT Distance Mapping Algorithm
The Journal of Bone and Joint Surgery (2025) 

Fayed A. et al.;
Weightbearing Computed Tomography Measurements in Progressive Collapsing Foot Deformity: A Contemporary Review
Foot & Ankle Orthopaedics(2025) 

Efrima B. et al.;
The Battleship technique: A reliable method to quantify intraarticular distance maps patterns and correlate hindfoot alignment
Journal of Experimental Orthopaedics (2025) 

Grün W. et al.;
Foot Malalignment and Proximal Fifth Metatarsal Fractures
Foot and Ankle International (2025) 

Lintz F. et al.;
A Hallux Valgus Surgical Planning Survey Using WBCT-based 3D Printing
Foot and Ankle Orthopaedics (2025) 

Wang C-S. et al.;
A Comprehensive Weightbearing Computed Tomography Study on Patients With Hallux Valgus: Exploring Multiplanar Deformity Interrelationships
Foot & Ankle International (2025) 

Requist M. et al.;
Osseous Morphology Differences in the Foot and Ankle Associated with Charcot-Marie-Tooth Disease
 JBMR Plus (2025) 

Talaski G. et al.;
Semi-automated Segmentation and Distance Mapping of Weight Bearing CT Data to Estimate Select Midfoot Joint Volumes
 Foot & Ankle International  (2025) 

Colombo E. et al.;
Mixed Reality-Assisted Surgical Planning of Flow-Augmentation Extracranial-Intracranial Bypass Surgery: A Technical Note
 World Neurosurgery  (2025) 

Alanen M. et al.;
Computer-aided three-dimensional analysis of carpal alignment in scaphoid nonunion advanced collapse wrists: A comparative study with scapholunate advanced collapse and healthy wrists
 BMC Musculoskeletal Disorders  (2025) 

Mansur N.S.B. et al.;
Correction of syndesmotic malreduction following fixation flexibilization
 Scientific Reports  (2025) 

de Cesar Netto C. et al.;
From Asymptomatic Flatfoot to Progressive Collapsing Foot Deformity
Peritalar Subluxation Is the Main Driver of Symptoms

 The Journal of Bone & Joint Surgery  (2025) 

Cho B.K. et al.;
Current Concepts of Radiographic Evaluation and Surgical Treatment for Hallux Valgus Deformity
Journal of Clinical Medicine  (2025) 

Efrima B. et al.;
Abnormal axial rotation of the Talus on weight-bearing computed tomography in patients with micro-instability of the ankle
Foot and Ankle Surgery (2025) 

de Cesar Netto C. et al.;
From Asymptomatic Flatfoot to Progressive Collapsing Foot Deformity
Peritalar Subluxation Is the Main Driver of Symptoms

The Journal of Bone and Joint Surgery (2025) 

Lalevée M. et al.;
Valgus Deviation of the Intersesamoid Crista in Hallux Valgus and Its Association With the Distal Metatarsal Articular Angle:  A Pilot Study
Foot & Ankle Orthopaedics (2025) 

Miyamoto T. et al.;
Description of Anatomical Differences in 3D Bone Morphology Between Female Individuals with Progressive Collapsing Foot Deformity and Asymptomatic Controls
The Journal of  Foot and Ankle Surgery (2025) 

Le A. et al.;
Cardan sequence selection influences subtalar and talonavicular joint kinematics
Journal of Biomechanics (2025) 

Zanuttini L. et al.;
Role of mixed reality in the workflow of complex neurooncological surgeries: a case analysis in thalamic surgery
Acta Neurochirurgica (2025) 

Grün W. et al.;
More Than Meets the Eye? Evaluating 3D Printing for Progressive Collapsing Foot Deformity Classification
The Journal of  Foot and Ankle Surgery (2025) 

Mallavarapu V. et al.;
 Weightbearing CT 3-D Mapping of First Metatarsophalangeal and Sesamoid Joint Interactions in Hallux Valgus: A Case-Control Study
Foot & Ankle International (2025) 

Requist M. et al.;
 Statistical Shape Modeling Characterization of Cavovarus Deformity Between Demyelinating and Axonal Subtypes of Charcot-Marie-Tooth Disease
Foot & Ankle International (2025) 

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